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KMID : 0370220100540030200
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Yakhak Hoeji
2010 Volume.54 No. 3 p.200 ~ p.204
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Synthesis of 7-Aryloxy-chroman-2-carboxamides and their Evaluation of NF- Inhibitory Activities
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Choi Eun-Hwa
Kwak Jae-Hwan
Kim Young-Soo
Lee Hee-Soon
Jung Jae-Kyung
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Abstract
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Nuclear factor- (NF-) plays critical roles in physiological and pathological processes such as immune function, cellular growth, homeostasis, apoptosis, and inflammation. As part of our ongoing efforts to develop novel NF- inhibitory agents, we reported that KL-1156 (6-hydroxy-7-methoxychroman-2-carboxylic acid phenylamide) exhibited potent inhibitory activity of NF-. For further structure-activity relationship, a series of 7-aryloxy-chroman-2-carboxylamide derivatives were synthesized to explore their inhibitory activities of NF-.
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KEYWORD
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NF-, KL-1156, chroman, diaryl ether
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